Susan M Pullen Selected Research

PR-104

1/2015	Pre-clinical activity of PR-104 as monotherapy and in combination with sorafenib in hepatocellular carcinoma.
11/2014	Dual targeting of hypoxia and homologous recombination repair dysfunction in triple-negative breast cancer.
5/2009	DNA cross-links in human tumor cells exposed to the prodrug PR-104A: relationships to hypoxia, bioreductive metabolism, and cytotoxicity.
7/2007	Mechanism of action and preclinical antitumor activity of the novel hypoxia-activated DNA cross-linking agent PR-104.

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Susan M Pullen Research Topics

Disease

5	Hypoxia (Hypoxemia) 01/2015 - 06/2007
5	Neoplasms (Cancer) 11/2014 - 03/2002
1	Hepatocellular Carcinoma (Hepatoma) 01/2015
1	Triple Negative Breast Neoplasms 11/2014
1	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 03/2014

Drug/Important Bio-Agent (IBA)

5	ProdrugsIBA 11/2014 - 03/2002
4	DNA (Deoxyribonucleic Acid)IBA 01/2015 - 07/2007
4	PR-104IBA 01/2015 - 07/2007
3	PR-104AIBA 03/2014 - 07/2007
2	Hydroxylamine (Hydroxylamine Hydrochloride)IBA 01/2015 - 07/2007
2	Cytotoxins (Cytolysins)IBA 11/2014 - 06/2007
2	tretazicarIBA 06/2004 - 03/2002
1	Oxidoreductases (Dehydrogenase)IBA 01/2015
1	AminesIBA 01/2015
1	Sorafenib (BAY 43-9006)FDA Link 01/2015
1	Aldo-Keto ReductasesIBA 01/2015
1	Cisplatin (Platino)FDA LinkGeneric 11/2014
1	Pharmaceutical PreparationsIBA 11/2014
1	NitrogenIBA 11/2014
1	SN 34037IBA 03/2014
1	Messenger RNA (mRNA)IBA 03/2014
1	Biomarkers (Surrogate Marker)IBA 05/2009
1	nitromide (Unistat)IBA 07/2007
1	Tirapazamine (SR 4233)IBA 07/2007
1	Docetaxel (Taxotere)FDA Link 07/2007
1	Mechlorethamine (Nitrogen Mustard)FDA Link 07/2007
1	Gemcitabine FDA Link 07/2007
1	Oxygen (Dioxygen)IBA 06/2007
1	NADPH-Ferrihemoprotein Reductase (Cytochrome P450 Reductase)IBA 06/2007
1	SolutionsIBA 06/2007
1	EnzymesIBA 03/2002

Therapy/Procedure

1	Radiotherapy 07/2007
1	Aftercare (After-Treatment) 07/2007
1	Drug Therapy (Chemotherapy) 07/2007
1	Therapeutics 03/2002